S.E.M.I. – Side Effects May Include...

S.E.M.I. – Side Effects May Include...

Can my PC run S.E.M.I. – Side Effects May Include...

Find out whether your PC can run this game by reviewing the minimum and recommended requirements below.

RAM 8 GB+ Storage 3 GB+ Windows 10

Game Details

Languages
English، Russian، French، German، Spanish - Spain، Simplified Chinese، Portuguese - Brazil، Japanese، Korean
Genre
Action، Indie
Category
Single-player، Multi-player، Co-op، Online Co-op، Steam Achievements، Full Controller Support، Custom Volume Controls، Playable Without Timed Input، Stereo Sound، Surround Sound، Family Sharing
Developer
Two Horn Unicorn
Publisher
Two Horn Unicorn
Release Date
2026-01-23

Minimum Requirements

CPU
Intel Core i5 series / Ryzen series
GPU
GTX 960 / Samsung Xclipse 960 / Xclipse 960 / 960 / AMD R9 290
RAM
8 GB
Storage
3 GB
OS
Windows 10

Recommended Requirements

CPU
Intel Core i7 series / Ryzen series
GPU
GTX 1660 / NVIDIA GeForce GTX 1660 Ti / 1660 / RX6600 / RX 6600
RAM
8 GB
Storage
3 GB
OS
Windows 11

Game Description

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here, you and up to 3 of your brainless loyal friends play as patients, fighting staff and other patients while stumbling into all sorts of unexpected situations. Brawls, side-effect pills, and brutal platforming will absolutely challenge your clumsy friends’ hands sense of teamwork. Expect obstacles, puzzles, deadly traps, and rooms where a single wrong move can knock out the entire squad.

Communicate in voice chat and arrange sabotage help your friends pass through rooms, get out of traps and fight with opponents! In your arsenal: close combat, physics, amazing abilities and ... imagination!

Take pills and get abilities:

  • Bipolar force is an invulnerable monster, then a helpless rag!

  • Laser astigmatism — two sights, one laser… Where will he shoot?

  • Stendhal syndrome — are you looking at a painting? Now you're hysterical and destroying everything around you!

  • Alice's syndrome is either tiny or gigantic — have time to adjust!

Madness is near! You and your friends can go crazy and start running, jumping and fighting, and your abilities will become uncontrollable. Do you want to take back control? Take the pills :)

Locations are randomly generated from rooms with changing gravity, traps, moving walls, and other "pleasant" surprises.

After a successful escape, you will receive a medical report: "The patient was stable until he started hitting the guards with a bottle. Diagnosis: Overmotivation" or something worse!

Unlock new costumes and decorations. Let each new escape be more stylish than the previous one!

Will you and your friends be able to escape... or at least not go crazy?

Welcome to the mental hospital! Here, your abilities are a lottery, and your friends can be the most dangerous opponents!